Near‐Infrared‐Emitting BODIPY‐trisDOTA111In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations. Issue 36 (2nd August 2016)

• Record Type: Journal Article
• Authors: Maindron, Nicolas; Ipuy, Martin; Bernhard, Claire; Lhenry, Damien; Moreau, Mathieu; Carme, Sabin; Oudot, Alexandra; Collin, Bertrand; Vrigneaud, Jean‐Marc; Provent, Peggy; Brunotte, François; Denat, Franck; Goze, Christine
• Is Part Of: Chemistry. Volume 22:Issue 36(2016)
• Page Start: 12670
• Page End: 12674
• Publication Date: 2016-08-02
• Subjects: bimodal probes -- BODIPY -- DOTA -- MOMIP -- optical imaging; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201602886
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A new generation of monomolecular imaging probes (MOMIP) based on a distyryl‐BODIPY (BODIPY=boron‐dipyrromethene) coupled with three DOTA macrocycles has been prepared (DOTA=1, 4, 7, 10‐tetraazacyclododecane‐1, 4, 7, 10‐tetraacetic acid). The MOMIP presents good fluorescence properties and is very stable in serum. The bimodal probe was conjugated to trastuzumab, and an optical in vivo study showed high accumulation of the imaging agent at the tumor site. 111 In radiometallation of the bioconjugate was performed in high radiochemical yield, highlighting the potential of this new BODIPY‐chelators derivative as a bimodal imaging probe. Abstract : A new generation of boron‐dipyrromethene (BODIPY)–trisDOTA monomolecular multimodal imaging probes for optical/single‐photon emission computed tomography (SPECT) imaging was developed and validated in vivo, highlighting the potential of the BODIPY fluorophore for future imaging developments. DOTA=1, 4, 7, 10‐tetraazacyclododecane‐1, 4, 7, 10‐tetraacetic acid.