A Pd‐Catalyzed Synthesis of Functionalized Piperidines. Issue 37 (5th July 2016)

• Record Type: Journal Article
• Authors: Allen, Benjamin D. W.; Connolly, Matthew J.; Harrity, Joseph P. A.
• Is Part Of: Chemistry. Volume 22:Issue 37(2016)
• Page Start: 13000
• Page End: 13003
• Publication Date: 2016-07-05
• Subjects: annulation -- enantioselectivity -- Pd catalysis -- piperidine; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201602586
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A readily available cyclic carbamate1 functions as a general precursor to a range of functionalized piperidine products via a new Pd‐catalyzed annulation strategy. An asymmetric catalytic variant provides a rapid and efficient means to access these heterocycles with high to excellent levels of enantiocontrol. Finally, these richly functionalized compounds are amenable to further chemoselective elaboration. Abstract : To cut a long story short… A cyclic carbamate functions as a general precursor to a range of functionalized piperidine products through a new Pd‐catalyzed annulation strategy. An asymmetric catalytic variant provides a rapid and efficient means to access these heterocycles with high to excellent levels of enantiocontrol.