Atypical cartilaginous tumor/chondrosarcoma, grade 1, of the mastoid in three family members: A new entity. (15th December 2015)

• Record Type: Journal Article
• Authors: Frisch, Christopher D.; Inwards, Carrie Y.; Lalich, Ian J.; Carter, Jodi M.; Neff, Brian A
• Is Part Of: Laryngoscope. Volume 126:Number 9(2016:Sep.)
• Page Start: E310
• Page End: E313
• Publication Date: 2015-12-15
• Subjects: Temporal bone tumor -- mastoid tumor -- temporal bone chondrosarcoma -- chondrosarcoma -- temporal bone cartilaginous tumor; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.25802
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : We present a case series of a family with three members having cartilaginous tumors of the mastoid. All patients presented between the ages of 9 to 12 years with acute onset facial nerve paralysis. Histologic analysis of all tumors showed similar features, consistent with atypical cartilaginous tumors/chondrosarcoma, low‐grade. Conventional cytogenetic analysis performed on one of the sons' tumor showed no evidence of chromosomal abnormality. High‐resolution array comparative genomic hybridization performed on the same patient's blood also showed no unbalanced chromosomal abnormality. This is the first report of family members with this unusual combination of clinical, radiologic, and histologic finding. Laryngoscope, 126:E310–E313, 2016