Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage. (27th July 2016)

• Record Type: Journal Article
• Authors: Ebina, Yasuhiko; Shimada, Shigeki; Deguchi, Masashi; Maesawa, Yoko; Iijima, Norifumi; Yamada, Hideto
• Is Part Of: American journal of reproductive immunology. Volume 76:Number 3(2016)
• Page Start: 199
• Page End: 204
• Publication Date: 2016-07-27
• Subjects: cytotoxic T cells -- helper T cells -- miscarriage -- pregnancy -- regulatory T cells; Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12546
• Languages: English
• ISSNs: 1046-7408

Abstract

Abstract : Problem: The aim of this prospective study was to evaluate phenotypic differences of helper T (Th), cytotoxic T (Tc), and regulatory T (Treg) cells in the deciduae of missed miscarriage with a normal chromosome karyotype of a fetus (MN) and missed miscarriage with an abnormal chromosome karyotype of a fetus (MA). Methods of study: The decidua of 19 MN and 28 MA was obtained. Additionally, the decidua of 15 induced abortion (IA) and the endometrium of 19 non‐pregnant women (EM) were obtained. IFN‐γ +, IL‐17 +, CD25 high Foxp3 + cells in CD4 + (Th) cells, and IFN‐γ + cells in CD8 + (Tc) cells were evaluated by flow cytometry. Results: The percentages of IFN‐γ + Tc and CD4 + CD25 high Foxp3 + (Treg) cells in MN were significantly increased as compared with MA and IA. The percentage of IFN‐γ + Th in MN was increased as compared with IA. Conclusion: Activation of IFN‐γ + Tc and Treg cells in the decidua might be associated with the pathophysiology underlying MN.