Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese. (7th February 2016)

• Record Type: Journal Article
• Authors: Li, Tianxiao; Ren, Zhimin; Deng, Ying; Wang, Yi; Zhou, Hongbo
• Is Part Of: Journal of asthma. Volume 53:Number 2(2016)
• Page Start: 114
• Page End: 118
• Publication Date: 2016-02-07
• Subjects: Asthma -- Han Chinese children -- RAD50 -- IL13 -- single-nucleotide polymorphism; Asthma -- Periodicals; 616.238005
• DOI: 10.3109/02770903.2015.1067322
• Languages: English
• ISSNs: 0277-0903

Abstract

Abstract: Objective : RAD50-IL13 region has been recently identified as one of critical asthma susceptibility loci in genome-wide association studies, yet the role of these genetic variants or single-nucleotide polymorphisms (SNPs) in the risk of developing asthma in Northeastern Han Chinese remains largely unknown. Methods : We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13 ) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method. Results : We did not find the allele or genotype frequency distribution of four SNPs in RAD50-IL13 region which was significantly different between asthmatic children and controls ( p > 0.05). Conclusions : Our findings first suggested that the variants in RAD50-IL13 region were not associated with asthma risk in Northeastern Han Chinese children.