Promoting brain health through exercise and diet in older adults: a physiological perspective. (6th January 2016)

• Record Type: Journal Article
• Authors: Jackson, Philippa A.; Pialoux, Vincent; Corbett, Dale; Drogos, Lauren; Erickson, Kirk I.; Eskes, Gail A.; Poulin, Marc J.
• Is Part Of: Journal of physiology. Volume 594:Number 16(2016:Aug.)
• Page Start: 4485
• Page End: 4498
• Publication Date: 2016-01-06
• Subjects: Physiology -- Periodicals; 612.005
• DOI: 10.1113/JP271270
• Languages: English
• ISSNs: 0022-3751

Abstract

Abstract : Age‐related changes in brain physiology. Ageing is associated with a number of structural, vascular and neuromolecular changes in the brain which contribute to impaired cognitive function. Modifiable lifestyle factors including physical activity, cognitive activity and a Mediterranean‐style diet may attenuate the progression of these changes and protect against cognitive decline. Abstract: The rise in incidence of age‐related cognitive impairment is a global health concern. Ageing is associated with a number of changes in the brain that, collectively, contribute to the declines in cognitive function observed in older adults. Structurally, the ageing brain atrophies as white and grey matter volumes decrease. Oxidative stress and inflammation promote endothelial dysfunction thereby hampering cerebral perfusion and thus delivery of energy substrates and nutrients. Further, the development of amyloid plaques and neurofibrillary tangles contributes to neuronal loss. Of interest, there are substantial inter‐individual differences in the degree to which these physical and functional changes impact upon cognitive function as we grow older. This review describes how engaging in physical activity and cognitive activities and adhering to a Mediterranean style diet promote 'brain health'. From a physiological perspective, we discuss the effects of these modifiable lifestyle behaviours on the brain, and how some recent human trials are beginning to show some promise as to the effectiveness of lifestyle behaviours in combating cognitive impairment. Moreover, we propose that these lifestyle behaviours, through numerous mechanisms, serve to increase brain, cerebrovascular and cognitive reserve, thereby preserving and enhancing cognitive function for longer.