A simple quinoline-derived fluorescent sensor for the selective and sequential detection of copper(ii) and sulfide ions and its application in living-cell imaging. Issue 81 (16th August 2016)

• Record Type: Journal Article
• Authors: Liu, Haiyang; Wu, Fengxu; Zhang, Bibo; Tan, Chunyan; Chen, Yuzong; Hao, Gefei; Tan, Ying; Jiang, Yuyang
• Is Part Of: RSC advances. Volume 6:Issue 81(2016)
• Page Start: 77508
• Page End: 77514
• Publication Date: 2016-08-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra15938a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : QLBA as a fluorescent chemosensor for Cu 2+ detection, and its corresponding complex as a cascade sensor for the recognition of S 2− in living cells (SC denotes solution circumstance). Abstract : A simple amide compound (QLBA), prepared from quinoline-2-carboxylic acid and 2-(1H-benzo[ d ]imidazol-2-yl)aniline, was synthesized and evaluated as an efficient fluorescence chemosensor for the selective recognition of copper ions (Cu 2+ ). This sensor could detect Cu 2+ in CH3 OH/HEPPES buffer in a wide pH range (4.0–10.0), with obvious fluorescence quenching. The obtained QLBA–Cu 2+ complex could be used as a new cascade sensor for detecting sulfide anions (S 2− ). The corresponding detection limits were found to be 2.2 × 10 −7 M for Cu 2+ and 4.6 × 10 −7 M for S 2− . The sensing mechanisms of QLBA toward Cu 2+ were systematically investigated in detail by NMR, HR-MS analysis, and density functional theory (DFT) calculations. In addition, this sensor was verified to be of low cytotoxicity and to have good imaging characteristics for the detection of Cu 2+ and further for the recognition of S 2− in living cells, suggesting that QLBA was a useful tool for tracking Cu 2+ and S 2− ions in vivo .