ChemInform Abstract: Broensted Base‐Catalyzed Three‐Component Coupling Reaction of α‐Ketoesters, Imines, and Diethyl Phosphite Utilizing [1, 2]‐Phospha‐Brook Rearrangement. Issue 39 (September 2016)

• Record Type: Journal Article
• Authors: Kondoh, Azusa; Terada, Masahiro
• Is Part Of: ChemInform. Volume 47:Issue 39(2016)
• Page Start: no
• Page End: no
• Publication Date: 2016-09
• Subjects: organo‐phosphorus compounds -- multicomponent reactions -- rearrangements; Chemistry -- Abstracts -- Periodicals; 540.5
• DOI: 10.1002/chin.201639198
• Languages: English
• ISSNs: 0931-7597

Abstract

Abstract: The title reaction involves the generation of ester enolates via the umpolung process, i.e., the chemoselective addition of diethyl phosphite to α‐ketoesters followed by [1, 2]‐phospha‐Brook rearrangement, and the trapping of the resulting enolates by imines preferentially over α‐ketoesters and protons.