Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications. (19th July 2016)

• Record Type: Journal Article
• Authors: Kong, Feng; Zhang, Hongbo; Zhang, Xu; Liu, Dongfei; Chen, Dong; Zhang, Weixia; Zhang, Liyuan; Santos, Hélder A.; Hai, Mingtan
• Is Part Of: Advanced functional materials. Volume 26:Number 34(2016)
• Page Start: 6158
• Page End: 6169
• Publication Date: 2016-07-19
• Subjects: biomedical applications -- enzyme and antibody co‐delivery -- multidrug resistance inhibition -- photothermal and pH responsiveness -- targeted cancer therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201602715
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : A biodegradable multifunctional carrier for combination therapy with high efficiency and low side effect is essential for effective cancer treatment and for advancing biomedical applications. Therapeutics combination could reduce multidrug resistance and minimize doses through synergism. This study develops biodegradable gold nanorods@calcium carbonate particles coated with pH‐responsive acetalated dextran and phospholipid as an advanced platform for the incorporation of versatile molecular targeted therapeutics, including hydrophilic and hydrophobic drugs, as well as the model enzyme, green fluorescent protein, or antibody. The developed calcium carbonate based hybrid particles show good biocompatibility, stability with photothermal, and pH responsiveness, which protect the payloads from premature release, and maintain the enzyme activity. The therapeutics co‐loaded CaCO3 based hybrid particles efficiently induce cancer cell death and reduce the multidrug resistance and HER2 expression with synergism. The photothermal effects promote ultrafast therapeutics release and induce significant cytotoxicity. Importantly, Anti‐HER2 antibody or HER2 targeted therapeutic is more effective in reducing HER2 expression when combined with drug or drugs via synergism. Overall, the cheap and simply manufactured biodegradable hybrid platform has great potential for advancing biomedical applications, including targeted photothermal combination therapy by co‐delivery of different types of therapeutics, including molecular targeted drugs, antibodies, and enzymes. Abstract : The biodegradable photothermal and pH responsive CaCO3 @Phospholipid@Acetalated Dextran hybrid platform is developed for advancing biomedical applications by co‐delivery of versatile molecular targeted therapeutics, enzyme, and antibody. The versatile therapeutics co‐loaded AuNRs@CaCO3 ‐POPC‐AcDX hybrid platform could effectively promote cancer cell death and reduce the multidrug resistance and HER2 expression with synergism.