Viruses and bacteria in Th2‐biased allergic airway disease. Issue 10 (20th July 2016)

• Record Type: Journal Article
• Authors: Lan, F.; Zhang, N.; Gevaert, E.; Zhang, L.; Bachert, C.
• Is Part Of: Allergy. Volume 71:Issue 10(2016:Oct.)
• Page Start: 1381
• Page End: 1392
• Publication Date: 2016-07-20
• Subjects: allergy rhinitis -- asthma -- chronic rhinosinusitis -- microbiome -- Th2 response; Allergy -- Periodicals; 616.97
• DOI: 10.1111/all.12934
• Languages: English
• ISSNs: 0105-4538

Abstract

Abstract: Allergic airway diseases are typically characterized by a type 2‐biased inflammation. Multiple distinct viruses and bacteria have been detected in the airways. Recently, it has been confirmed that the microbiome of allergic individuals differs from that of healthy subjects, showing a close relationship with the type 2 response in allergic airway disease. In this review, we summarize the recent findings on the prevalence of viruses and bacteria in type 2‐biased airway diseases and on the mechanisms employed by viruses and bacteria in propagating type 2 responses. The understanding of the microbial composition and postinfectious immune programming is critical for the reconstruction of the normal microflora and immune status in allergic airway diseases.