Real‐life experience with liver iron concentration R2 MRI measurement in patients with hemoglobinopathies: baseline data from LICNET. (23rd February 2016) - Vitrano, Angela
Abstract: Background: Real‐life data on the use of R2 MRI for the assessment of liver iron concentration (LIC) remain limited. Methods: We conducted a cross‐sectional analysis on 363 patients (mean age 35.6 yr, 44.1% men) with hemoglobinopathies (204 β ‐thalassemia major [TM], 102 β ‐thalassemia intermedia [TI], and 57 sickle cell disease [SCD]) that were evaluated with R2 MRI as part of LICNET, an MRI network of 13 Italian treatment centers. Results: The mean LIC was 7.8 mg/g (median: 4.0), with high LIC (>7 mg/g) noted in both transfused (TM, TI 37%; SCD 38%) and non‐transfused (TI 20%) patients. Ferritin levels correlated with LIC in both transfused (TM, TI, SCD) and non‐transfused (TI) patients ( P < 0.001), although lower values predicted high LIC in non‐transfused patients (1900 vs. 650 ng/mL in TM vs. non‐transfused TI). A correlation between LIC and ALT levels was only noted in HCV‐negative patients (rs = 0.316, P < 0.001). The proportion of patients with high LIC was significantly different between iron chelators used ( P = 0.023), with the lowest proportion in deferasirox (30%) and highest in deferiprone (53%)‐treated patients. Conclusions: High LIC values persist in subgroups of patients with hemoglobinopathy, warranting closer monitoring and management optimization, even for non‐transfused patients with relatively low ferritin levels.