Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti‐MicroRNA Therapies. Issue 36 (6th July 2016)

• Record Type: Journal Article
• Authors: Beavers, Kelsey R.; Werfel, Thomas A.; Shen, Tianwei; Kavanaugh, Taylor E.; Kilchrist, Kameron V.; Mares, Jeremy W.; Fain, Joshua S.; Wiese, Carrie B.; Vickers, Kasey C.; Weiss, Sharon M.; Duvall, Craig L.
• Is Part Of: Advanced materials. Volume 28:Issue 36(2016)
• Page Start: 7984
• Page End: 7992
• Publication Date: 2016-07-06
• Subjects: anti‐miRNA -- nanocomposite -- peptide nucleic acids -- PNA -- porous silicon; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201601646
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Self‐assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti‐microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug‐cargo‐loading capacity. Functionalization with a diblock polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics, and intracellular bioavailability through endosomal escape, enabling PNA to inhibit miR‐122 in vivo.