Asymmetric Ring Opening/Cyclization/Retro‐Mannich Reaction of Cyclopropyl Ketones with Aryl 1, 2‐Diamines for the Synthesis of Benzimidazole Derivatives. (4th July 2016)
- Record Type:
- Journal Article
- Title:
- Asymmetric Ring Opening/Cyclization/Retro‐Mannich Reaction of Cyclopropyl Ketones with Aryl 1, 2‐Diamines for the Synthesis of Benzimidazole Derivatives. (4th July 2016)
- Main Title:
- Asymmetric Ring Opening/Cyclization/Retro‐Mannich Reaction of Cyclopropyl Ketones with Aryl 1, 2‐Diamines for the Synthesis of Benzimidazole Derivatives
- Authors:
- Xia, Yong
Lin, Lili
Chang, Fenzhen
Liao, Yuting
Liu, Xiaohua
Feng, Xiaoming - Abstract:
- Abstract: A highly efficient asymmetric ring‐opening/cyclization/retro‐Mannich reaction of cyclopropyl ketones with aryl 1, 2‐diamines has been realized using a chiral N, N′ ‐dioxide/Sc III catalyst. Benzimidazoles containing chiral side chains were generated under mild reaction conditions in excellent outcomes (up to 99 % yield and 97 % ee ). This method also provides efficient access to chiral benzimidazole‐substituted amide and cycloheptene derivatives.
- Is Part Of:
- Angewandte Chemie. Volume 128:Number 40(2016)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 128:Number 40(2016)
- Issue Display:
- Volume 128, Issue 40 (2016)
- Year:
- 2016
- Volume:
- 128
- Issue:
- 40
- Issue Sort Value:
- 2016-0128-0040-0000
- Page Start:
- 12416
- Page End:
- 12420
- Publication Date:
- 2016-07-04
- Subjects:
- Asymmetrische Katalyse -- Enantioselektivität -- Heterocyclen -- Kleinringsysteme -- Scandium
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201604735 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 64.xml