Manganese(I)‐Catalyzed C−H Activation: The Key Role of a 7‐Membered Manganacycle in H‐Transfer and Reductive Elimination. (7th September 2016)

• Record Type: Journal Article
• Authors: Yahaya, Nasiru P.; Appleby, Kate M.; Teh, Magdalene; Wagner, Conrad; Troschke, Erik; Bray, Joshua T. W.; Duckett, Simon B.; Hammarback, L. Anders; Ward, Jonathan S.; Milani, Jessica; Pridmore, Natalie E.; Whitwood, Adrian C.; Lynam, Jason M.; Fairlamb, Ian J. S.
• Is Part Of: Angewandte Chemie. Volume 128:Number 40(2016)
• Page Start: 12643
• Page End: 12647
• Publication Date: 2016-09-07
• Subjects: C-H-Aktivierung -- Funktionalisierungen -- Katalyse -- Mangan -- Nachhaltigkeit; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201606236
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Manganese‐catalyzed C−H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven‐membered Mn I intermediate is detected and characterized that is effective for H‐transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at Mn I by judicious choice of an electron‐deficient 2‐pyrone substrate containing a 2‐pyridyl directing group, which undergoes regioselective C−H bond activation, serving as a valuable system for probing the mechanistic features of Mn C−H bond activation chemistry.