A Kinetic Self‐Sorting Approach to Heterocircuit [3]Rotaxanes. Issue 40 (7th September 2016)

• Record Type: Journal Article
• Authors: Neal, Edward A.; Goldup, Stephen M.
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 40(2016)
• Page Start: 12488
• Page End: 12493
• Publication Date: 2016-09-07
• Subjects: active templates -- cycloaddition -- CuAAC -- rotaxanes -- self-sorting; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201606640
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: In this proof‐of‐concept study, an active‐template coupling is used to demonstrate a novel kinetic self‐sorting process. This process iteratively increases the yield of the target heterocircuit [3]rotaxane product at the expense of other threaded species. Abstract : If at first you don't succeed, fall apart : A novel self‐sorting approach is described in which the kinetic stability of the desired [3]rotaxane isomer determines the reaction outcome. All other threaded structures derived from the larger ring are kinetically unstable, allowing the yield of the target to be amplified at the expense of other possible products.