A prospective study of dietary patterns and cancer mortality among Blacks and Whites in the REGARDS cohort. Issue 10 (9th August 2016)

• Record Type: Journal Article
• Authors: Akinyemiju, Tomi; Moore, Justin Xavier; Pisu, Maria; Lakoski, Susan G.; Shikany, James; Goodman, Michael; Judd, Suzanne E.
• Is Part Of: International journal of cancer. Volume 139:Issue 10(2016:Nov. 15)
• Page Start: 2221
• Page End: 2231
• Publication Date: 2016-08-09
• Subjects: diet -- cancer -- mortality -- racial disparities -- prospective cohort; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.30287
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : Marked racial differences exist in dietary patterns and obesity, as well as cancer mortality. This study aims to assess whether dietary patterns are associated with cancer mortality overall and by race. We identified 22, 041 participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Dietary patterns were categorized into: Convenience (Chinese and Mexican foods, pasta, pizza), Plant‐based (fruits, vegetables), Southern (added fats, fried foods, sugar‐sweetened beverages), Sweets/Fats (sugary foods) and Alcohol/Salads (alcohol, green‐leafy vegetables, salad dressing). Using Cox regression, we examined the association between quartiles of dietary patterns and cancer mortality, adjusted for potential confounders, overall among all participants and stratified by race. A total of 873 cancer deaths were observed over the 10‐year observation period: 582 (66.7%) in Whites and 291 (33.3%) in Blacks. Greater adherence to the Southern dietary pattern was associated with an increased risk of cancer mortality (4th vs . 1st quartile HR: 1.67; 95% CI: 1.32–2.10) overall, especially among Whites (4th vs . 1st quartile HR: 1.59; 95% CI: 1.22–2.08). The convenience (HR: 0.73; 95% CI: 0.56–0.94) and Plant‐based (HR: 0.72; 95% CI: 0.55–0.93) dietary patterns were associated with up to a 28% reduced risk of cancer mortality, but only among Whites. Greater adherence to the Southern dietary pattern increased the risk of cancer mortality, while greater adherence to the convenience and Plant‐based diets reduced the risk of cancer mortality among Whites. Racial differences were observed in the association between dietary patterns and cancer mortality, but warrant further study. Abstract : What's new? In the United States, obesity and cancer mortality differ between races, raising questions about whether interactions between dietary patterns and race influence cancer outcomes. In this investigation of Black and White adults in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, greater adherence to "Southern" dietary patterns, characterized by consumption of added fats, fried foods and sugar‐sweetened beverages, was associated with a twofold increase in cancer mortality in both racial groups. In whites only, "plant‐based" and "convenience" dietary patterns were associated with reduced cancer mortality. Avoiding aspects of the Southern diet could improve cancer outcomes for Blacks and Whites.