Exploring thiol‐yne based monomers as low cytotoxic building blocks for radical photopolymerization. Issue 21 (2nd August 2016)

• Record Type: Journal Article
• Authors: Oesterreicher, Andreas; Ayalur‐Karunakaran, Santhosh; Moser, Andreas; Mostegel, Florian H.; Edler, Matthias; Kaschnitz, Petra; Pinter, Gerald; Trimmel, Gregor; Schlögl, Sandra; Griesser, Thomas
• Is Part Of: Journal of polymer science. Volume 54:Issue 21(2016)
• Page Start: 3484
• Page End: 3494
• Publication Date: 2016-08-02
• Subjects: low cytotoxicity -- photopolymers -- thiol‐yne; 547
• DOI: 10.1002/pola.28239
• Languages: English
• ISSNs: 0887-624X

Abstract

ABSTRACT: The last decade has seen a remarkable interest in the development of biocompatible monomers for the realization of patient specific medical devices by means of UV‐based additive manufacturing technologies. This contribution deals with the synthesis and investigation of novel thiol‐yne based monomers with a focus on their biocompatibility and also the mechanical properties in their cured state. It could be successfully shown that propargyl and but‐1‐yne‐4‐yl ether derivatives have a significant lower cytotoxicity than the corresponding (meth)acrylates with similar backbones. Together with appropriate thiol monomers, these compounds show reactivities in the range of (meth)acrylates and almost quantitative triple bond conversions. A particular highlight is the investigation of the network properties of photo cured alkynyl ether/thiol resins by means of low field solid state nuclear magnetic resonance spectroscopy. Additionally, dynamic mechanical analysis of those polymers revealed that monomers containing rigid backbones lead to moduli and glass transition temperatures ( T g 's), sufficiently high for the fabrication of medical devices by UV based additive manufacturing methods. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem.2016, 54, 3484–3494 Abstract : New monomers for thiol‐yne based photopolymers were synthesized and characterized. It could be successfully shown that these building blocks provide significant lower cytotoxicity than the corresponding (meth)acrylates and offer comparably high reactivities. Network and mechanical properties of derived polymers were studied by dynamic mechanical thermal analysis (DMA) and low‐field solid‐state NMR. It turned out that monomers containing rigid backbones lead to moduli and glass transition temperatures, sufficiently high for the fabrication of medical devices.