Vaccines for the prevention against the threat of MERS-CoV. (1st September 2016)

• Record Type: Journal Article
• Authors: Du, Lanying; Tai, Wanbo; Zhou, Yusen; Jiang, Shibo
• Is Part Of: Expert review of vaccines. Volume 15:Number 9(2016)
• Page Start: 1123
• Page End: 1134
• Publication Date: 2016-09-01
• Subjects: Animal models -- immune responses -- MERS -- MERS-CoV -- neutralizing antibody -- protection -- spike protein -- vaccines; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1586/14760584.2016.1167603
• Languages: English
• ISSNs: 1476-0584

Abstract

ABSTRACT: First identified in 2012, Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is listed as a new Category C Priority Pathogen. While the high mortality of MERS-CoV infection is further intensified by potential human-to-human transmissibility, no MERS vaccines are available for human use. This review explains immune responses resulting from MERS-CoV infection, describes MERS vaccine criteria, and presents available small animal models to evaluate the efficacy of MERS vaccines. Current advances in vaccine development are summarized, focusing on specific applications and limitations of each vaccine category. Taken together, this review provides valuable guidelines toward the development of an effective and safe MERS vaccine. This article is written for a Special Focus Issue of Expert Review of Vaccines on 'Vaccines for Biodefence'.