Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery: Case report. Issue 39 (September 2016)

• Record Type: Journal Article
• Authors: Lee, Chaw-Ning; Pan, Shin-Chen; Lee, Julia Yu-Yun; Wong, Tak-Wah
• Editors: Li., Jianfeng
• Is Part Of: Medicine. Volume 95:Issue 39(2016)
• Page Start: e4991
• Publication Date: 2016-09
• Subjects: case report -- intralesional cryosurgery -- keratoacanthoma -- squamous cell carcinoma; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000004991
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Wide excision or Mohs surgery is the standard treatment of skin squamous cell carcinoma (SCC). Superficial SCC or tumor smaller than 1 cm has been treated successfully with open spray cryosurgery. Larger tumor may not be as effective because tissue destruction is usually superficial. Intralesional cryosurgery (IC) may provide a deeper and better cell killing effect in larger tumors. We investigated the safety and efficacy of treating nodular SCC in 4 patients with IC. Methods: Four patients with nodular SCC/keratoacanthoma (tumor size, 1–2.5 cm, average 1.48 cm) on the face and extremity were treated with IC. An 18-ga needle was connected to a cryogun and inserted into the center of the tumor after local anesthesia. The tumors were treated with 2 freeze–thaw cycles with a 5- to 10-mm free margin. Additional IC or open spray cryosurgery was applied if residual tumor was noted during monthly follow-up. Results: No patient required analgesics or experienced wound infection after the procedures. After IC, all tumors reduced 40% to 75% in size within 1 week. Two patients received 1 additional spray cryosurgery. Complete remission was noted in all tumors (100%) in 2 months. No recurrence was noted during follow-up (average 5.1 years). All patients were satisfied with the results. Conclusion: Our observation suggests that IC can be simple and effective alternative treatment for SCC patients whose condition is not suitable for or who refused operation.