Catalyst- and oxidant-free coupling of disulfides with H-phosphine oxide: construction of P–S bond leading to thiophosphinates. Issue 42 (19th October 2016)

• Record Type: Journal Article
• Authors: Xia, Minfang; Cheng, Jiang
• Is Part Of: Tetrahedron letters. Volume 57:Issue 42(2016)
• Page Start: 4702
• Page End: 4704
• Publication Date: 2016-10-19
• Subjects: Catalyst- and oxidant-free -- Disulfides -- H-phosphine oxide -- Coupling of P–S bond; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.09.021
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Neither catalyst nor oxidant was required in this procedure. This strategy features high efficiency with operational simplicity. Silver was not required in this transformation at all. Abstract: An efficient protocol for the synthesis of thiophosphinates is presented, involving direct coupling of P–S bond between disulfides and H-phosphine oxide in moderate to good yields with good functional group compatibility. This procedure shows some advantages: (1) catalyst- and oxidant-free; (2) high efficiency with operational simplicity.