One pot, simple, and efficient synthesis of (E)- and (Z)-3-allylidene-β-lactams from 3-allyl-3-phenylseleno-β-lactams: analogues of β-lactamase inhibitors. Issue 42 (19th October 2016) - Bhalla, Aman
Graphical abstract: Highlights: Exploration of oxidation and β-elimination in one step. Stereoselective synthesis of ( E )-3-allylidene-β-lactams. Simple, efficient, fast (12–18 min) methodology to earlier reported ones (12–90 h). Use of dichloromethane as solvent in place of unsafe carbon tetrachloride. 3-Allyl-3-phenylseleno-β-lactams: versatile & easily prepared substrates. Abstract: The direct synthesis of ( E )- and ( Z )-3-allylidene-β-lactams from 3-allyl-3-phenylseleno-β-lactams under mild conditions has been described. 3-Allyl-3-phenylseleno-β-lactams acts as an efficient substrate for in situ oxidation and elimination in one step. This method is simple, convenient, fast, and very efficient.