Does perfusion CT play a role in the evaluation of percutaneous microwave-ablated lung tumours?. Issue 11 (November 2016)

• Record Type: Journal Article
• Authors: Parvizi, N.; Chung, D.; Little, M.W.; Gleeson, F.V.; Anderson, E.M.
• Is Part Of: Clinical radiology. Volume 71:Issue 11(2016)
• Page Start: 1137
• Page End: 1142
• Publication Date: 2016-11
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2016.07.005
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : Aim: To assess the clinical utility of perfusion computed tomography (pCT) parameters in microwave ablation (MWA) of lung tumours. Materials and methods: Patients were included who had primary or metastatic lung tumours and underwent pCT studies immediately pre- and post-MWA. Perfusion maps of the tumours were constructed using CT perfusion software (GE, Milwaukee, WI, USA). Regions of interest were drawn on sequential axial sections to extract the pCT parameters, blood volume (BV), average blood flow (BF), and mean transit time (MTT) from the entire tumour volume. Direct visualisation of perfusion maps were performed by two experienced readers blinded to outcome. Data were analysed using the Mann–Whitney test. Results: Thirty-one patients with 34 lung tumours had follow-up data at 12 months. The median tumour diameter was 19 mm (10–52 mm). Seven patients developed local tumour progression (LTP) at 12 months. There was no statistical difference between patients with LTP and complete treatment based on quantitative pCT parameters. Using radiologist visualisation of perfusion maps, there was moderate agreement between the two readers (kappa coefficient 0.53) with a combined 96% sensitivity, 62% specificity, 91% positive predictive value, and 80% negative predictive value. Conclusion: Quantitative pCT parameters do not help differentiate between LTP and complete treatment, but subjective analysis of perfusion maps may be a useful assessment tool for identifying treatment adequacy potentially enabling identification of areas requiring further treatment at the time of the procedure. Highlights: Minimally invasive percutaneous thermal ablation has grown in popularity as a treatment option for lung tumours of lung tumours. pCT may be of value in predicting and assessing thermal ablation success. Quantitative pCT parameters do not help differentiate between local tumour control and complete treatment. Visual assessment of pCT maps may be a useful assessment tool for identifying treatment adequacy.