Biomarkers in Persistent AF and Heart Failure: Impact of Catheter Ablation Compared with Rate Control. Issue 9 (17th August 2016)

• Record Type: Journal Article
• Authors: JONES, DAVID G.; HALDAR, SHOUVIK K.; DONOVAN, JACQUELINE; MCDONAGH, THERESA A.; SHARMA, RAKESH; HUSSAIN, WAJID; MARKIDES, VIAS; WONG, TOM
• Is Part Of: Pacing and clinical electrophysiology. Volume 39:Issue 9(2016)
• Page Start: 926
• Page End: 934
• Publication Date: 2016-08-17
• Subjects: atrial fibrillation -- biomarkers -- catheter ablation -- heart failure -- rate control; Cardiac pacing -- Periodicals; Electrophysiology -- Periodicals; 617.4120645
• DOI: 10.1111/pace.12919
• Languages: English
• ISSNs: 0147-8389

Abstract

Abstract : Background: To investigate the effects of catheter ablation and rate control strategies on cardiac and inflammatory biomarkers in patients with heart failure and persistent atrial fibrillation (AF). Methods: Patients were recruited from the ARC‐HF trial (catheter Ablation vs Rate Control for management of persistent AF in Heart Failure, NCT00878384), which compared ablation with rate control for persistent AF in heart failure. B‐type natriuretic peptide (BNP), midregional proatrial natriuretic peptide (MR‐proANP), apelin, and interleukin‐6 (IL‐6) were assayed at baseline, 3 months, 6 months, and 12 months. The primary end point, analyzed per‐protocol, was changed from baseline at 12 months. Results: Of 52 recruited patients, 24 ablation and 25 rate control subjects were followed to 12 months. After 1.2 ± 0.5 procedures, sinus rhythm was present in 22 (92%) ablation patients; under rate control, rate criteria were achieved in 23 (96%) of 24 patients remaining in AF. At 12 months, MR‐proANP fell significantly in the ablation arm (–106.0 pmol/L, interquartile range [IQR] –228.2 to –60.6) compared with rate control (–28.7 pmol/L, IQR –69 to +9.5, P = 0.028). BNP showed a similar trend toward reduction (P = 0.051), with no significant difference in apelin (P = 0.13) or IL‐6 (P = 0.68). Changes in MR‐proANP and BNP correlated with peak VO2 and ejection fraction, and MR‐proANP additionally with quality‐of‐life score. Conclusions: Catheter ablation, compared with rate control, in patients with heart failure and persistent AF was associated with significant reduction in MR‐proANP, which correlated with physiological and symptomatic improvement. Ablation‐based rhythm control may induce beneficial cardiac remodeling, unrelated to changes in inflammatory state. This may have prognostic implications, which require confirmation by event end point studies.