Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study. Issue 5 (16th September 2014)

• Record Type: Journal Article
• Authors: De Caridi, Giovanni; Massara, Mafalda; Acri, Ignazio; Zavettieri, Salvatore; Grande, Raffaele; Butrico, Lucia; de Franciscis, Stefano; Serra, Raffaele
• Is Part Of: International wound journal. Volume 13:Issue 5(2016)
• Page Start: 754
• Page End: 758
• Publication Date: 2014-09-16
• Subjects: Hyaluronic acid -- Lower limbs -- PDRN -- Polynucleotides -- Venous ulcers; Wounds and injuries -- Treatment -- Periodicals; Wounds and injuries -- Periodicals; Wound healing -- Periodicals; 617.1005
• DOI: 10.1111/iwj.12368
• Languages: English
• ISSNs: 1742-4801

Abstract

Abstract: The aim of this study was to evaluate the results of treatment of venous lower limbs ulcers through the topical application of polynucleotides and hyaluronic acid gel (PNHA): Nucliaskin S™ (Mastelli srl, San Remo, Italy). This study was carried out in 39 consecutive patients who were randomly allocated to two groups: group I (20 patients) received treatment with PNHA (topical gel application two times a week, for a total of 6 weeks); group II (19 patients) received only hyaluronic acid (HA) topical application. All patients received a surgical debridement of the ulcerative lesions before topical treatment with PNHA or HA. Pre‐treatment data indicated the area of ulceration. The number of healed ulcers and the variation in area of ulceration were considered as endpoints. The endpoints were observed after 45 days from the beginning of treatment. Complete wound healing occurred in 60% of limbs of group I and in 22% of those of group II patients. The average area reduction was 67% versus 34% in patients of group I and II, respectively. No side effects were recorded in both groups. Our experience shows that PNHA has an elevated trophic effect and speeds the healing rate of venous lower limb ulcers. This treatment may be a valid option in clinical practice.