Escorted by chaperones: Sti1 helps to usher precursor proteins from the ribosome to mitochondria. (11th August 2016)

• Record Type: Journal Article
• Authors: Hansen, Katja G.; Schlagowski, Anna; Herrmann, Johannes M.
• Is Part Of: FEBS journal. Volume 283:Number 18(2016)
• Page Start: 3335
• Page End: 3337
• Publication Date: 2016-08-11
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.13821
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : Little is known about factors that interact with mitochondrial precursor proteins in the cytosol. Employing site‐specific crosslinking this study identifies chaperones of the Hsp70 and Hsp90 families as well as Sti1 as escorts of cytosolic preproteins. Sti1 presumably helps to hand‐over preproteins from Hsp70 to the Hsp90 system and thereby facilitates their binding to TOM receptors on the mitochondrial surface.