Endothioxopeptides: A conformational overview. Issue 5 (September 2016)

• Record Type: Journal Article
• Authors: De Zotti, Marta; Peggion, Cristina; Biondi, Barbara; Crisma, Marco; Formaggio, Fernando; Toniolo, Claudio
• Is Part Of: Biopolymers. Volume 106:Issue 5(2016)
• Page Start: 697
• Page End: 713
• Publication Date: 2016-09
• Subjects: conformational energy calculations -- endoselenoxopeptides -- endothioxopeptides -- fluorescence quenching -- peptide helices -- peptide turns -- solution conformation -- X‐ray diffraction; Biopolymers -- Periodicals; Peptides -- Periodicals; Spectrum analysis -- Periodicals; 572.33
• DOI: 10.1002/bip.22899
• Languages: English
• ISSNs: 0006-3525

Abstract

Abstract: Although thionamides would have been first prepared two centuries ago and their chemical and spectroscopic properties extensively investigated, only much more recently (since about 1985) a well deserved but still insufficient attention has been paid to their endothioxopeptide subfamily which nonetheless currently represents a rapidly emerging area of great scientific interest in the broader field of foldameric compounds based on biologically relevant building blocks. After two brief sections offering information on the unfortunately still limited number of endothioxopeptides discovered from natural sources but also on the impressive advancements registered in the last few years in their synthetic methods, this review article outlines the results of a detailed literature survey on the ongoing great, but not systematic, progress related to the conformational consequences generated by incorporating one (or more) thionamide group(s) into a polypeptide chain. Finally, a short discussion of the growing, but still in its infancy, class of the endoselenoxopeptide congeners is also presented.