Cyclophosphamide plus granulocyte‐colony stimulating factor for hematopoietic stem cell mobilization in patients with multiple myeloma. Issue 5 (5th September 2015)

• Record Type: Journal Article
• Authors: Lin, Tung‐Liang; Wang, Po‐Nan; Kuo, Ming‐Chung; Hung, Yu‐Hsing; Chang, Hung; Tang, Tzung‐Chih
• Is Part Of: Journal of clinical apheresis. Volume 31:Issue 5(2016)
• Page Start: 423
• Page End: 428
• Publication Date: 2015-09-05
• Subjects: multiple myeloma -- hematopoietic stem cell mobilization -- cyclophosphamide -- granulocyte‐colony stimulating factor -- autologous hematopoietic stem cell transplantation; Hemapheresis -- Periodicals; Blood -- Transfusion -- Periodicals; Blood -- Transfusion, Autologous -- Periodicals; Cell separation -- Periodicals; Leukapheresis -- Periodicals; Plasmapheresis -- Periodicals; 615.39
• DOI: 10.1002/jca.21421
• Languages: English
• ISSNs: 0733-2459

Abstract

Abstract : We retrospectively reviewed the results of cyclophosphamide (3 g/m 2 ), doxorubicin and dexamethasone plus granulocyte‐colony stimulating factor (G‐CSF) (ID‐CY/DOX group), low‐dose cyclophosphamide (2 g/m 2 ) plus G‐CSF (LD‐CY group) and G‐CSF alone (G‐CSF group) for stem cell mobilization in patients with multiple myeloma. A total of 89 patients with 93 mobilizations were included. Apheresis was started when total white blood cell (WBC) count >10 × 10 9 /L for ID‐CY/DOX and LD‐CY groups and after eight doses of G‐CSF (5 μg/kg twice daily) for G‐CSF group. For five mobilizations in ID‐CY/DOX group, the rate of successful mobilization (≥4.0 × 10 6 /kg CD34+ cells) was 80%. For 78 mobilizations in LD‐CY group, the successful rate was 80.8%. For 10 mobilizations in the G‐CSF group, the successful rate was 50%. The mean yield of CD34+ cells was higher in ID‐CY/DOX and LD‐CY groups as compared with that in G‐CSF group ( P = 0.026 and 0.020, respectively). There was no difference in the yield of CD34+ cells between ID‐CY/DOX and LD‐CY groups ( P = 0.831). After autologous stem cell transplantation, the days to neutrophil and platelet engraftment were similar in these three groups ( P = 0.713 and 0.821, respectively). In conclusion, we observed that ID‐CY/DOX and LD‐CY plus G‐CSF for stem cell mobilization resulted in a higher successful rate and higher stem cell yields than G‐CSF alone and their engraftment time were similar. Total WBC count >10 × 10 9 /L can be used as a guide to start apheresis in CY‐based stem cell mobilization. J. Clin. Apheresis 31:423–428, 2016. © 2015 Wiley Periodicals, Inc.