Pretreatment computed tomographic gross tumor volume as predictor of persistence of tracheostomy and percutaneous endoscopic gastrostomy tube in patients undergoing larynx preservation. Issue 10 (30th April 2016)

• Record Type: Journal Article
• Authors: Hurst, Newton J.; Pereira, Lucio M.; Dominello, Michael M.; Dyson, Gregory; Laszewski, Pamela; Robinette, Natasha; Lin, Ho‐Sheng; Yoo, George; Sukari, Ammar; Kim, Harold
• Is Part Of: Head & neck. Volume 38:Issue 10(2016)
• Page Start: 1455
• Page End: 1458
• Publication Date: 2016-04-30
• Subjects: laryngeal cancer -- larynx preservation -- functional outcomes -- prognosis quality of life; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24458
• Languages: English
• ISSNs: 1043-3074

Abstract

ABSTRACT: Background: Although larynx preservation affords patients improvements in laryngectomy‐free survival, little has been reported regarding the functional outcomes after larynx preservation. The purpose of this study was to report the predictive value of pretreatment CT‐gross tumor volume (GTV) for persistence of tracheostomy and percutaneous endoscopic gastrostomy (PEG) tube in larynx preservation patients. Methods: Each patient had a CT scan before initiation of therapy and the GTV was contoured. Results: Using recursive partitioning analysis (RPA), threshold GTVs of 27.16 cc and 12 cc were identified for association of time with tracheostomy and PEG tube, respectively. Median (95% confidence interval [CI]) times above and below these thresholds were 1.84 (1.06–not reached [NR]) and 0.75 (0.63–1.26) years, respectively ( p = .03) for time with tracheostomy and 1.75 (1.34–NR) and 0.84 (0.46–NR) years, respectively ( p = 0.10) for time with PEG tube. Conclusion: This study demonstrates that pretreatment CT‐GTV is predictive of an approximately 2.5‐fold and approximately 2‐fold, respectively, increase in time with tracheostomy and PEG tube. © 2016 Wiley Periodicals, Inc. Head Neck 38: First–1458, 2016