Intestinal‐type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment. Issue 10 (25th May 2016)

• Record Type: Journal Article
• Authors: Hoeben, Ann; van de Winkel, Linda; Hoebers, Frank; Kross, Kenneth; Driessen, Chantal; Slootweg, Pieter; Tjan–Heijnen, Vivianne C. G.; van Herpen, Carla
• Other Names: Eisele David W. sponsoringEditor.
• Is Part Of: Head & neck. Volume 38:Issue 10(2016)
• Page Start: 1564
• Page End: 1570
• Publication Date: 2016-05-25
• Subjects: intestinal‐type adenocarcinoma -- sinonasal adenocarcinoma -- treatment -- gene expression -- pathology; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24416
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Sinonasal intestinal‐type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized. Methods: Articles on ITAC histopathology, molecular profile, and current treatment options of this specific tumor were identified and reviewed, using the electronic databases Pubmed, Medline, Cochrane, and Web of Science. Results: This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC. Conclusion: More translational research is needed to identify druggable targets that may lead to a personalized treatment plan in order to improve long‐term outcome in patients with locally advanced and/or metastasized ITAC. © 2016 Wiley Periodicals, Inc. Head Neck 38: First–1570, 2016