Ytterbium(III) Trifluoromethanesulfonate Catalyzed Ring‐Opening C(sp3)−N Bond Formation of Benzoxazoles with Propargylic Alcohols. Issue 18 (17th August 2016)

• Record Type: Journal Article
• Authors: Liu, Wenfei; Sun, Yongqing; Zhao, Haiying; Li, Baoguo; Chen, Shufeng
• Is Part Of: ChemCatChem. Volume 8:Issue 18(2016)
• Page Start: 2894
• Page End: 2897
• Publication Date: 2016-08-17
• Subjects: C(sp3)−N bond formation -- heterocycles -- propargylic alcohols -- ring-opening reactions -- ytterbium; Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201600606
• Languages: English
• ISSNs: 1867-3880

Abstract

Abstract: A novel ytterbium(III) trifluoromethanesulfonate [Yb(OTf)3 ]‐catalyzed ring‐opening C(sp 3 )−N bond formation reaction of benzoxazole with propargylic alcohols was established. This reaction uses readily available starting materials and is operationally simple; it thus represents a practical method for the construction of highly functionalized substituted benzenes bearing aldehyde, propargylamine, and hydroxy groups with high atom economy. Abstract : Twists and benz : A novel ytterbium(III) trifluoromethanesulfonate [Yb(OTf)3 ]‐catalyzed ring‐opening C(sp 3 )−N bond formation reaction of benzoxazole with propargylic alcohols is developed. This new transformation makes it possible to construct highly functionalized substituted benzenes bearing aldehyde, propargylamine, and hydroxy groups from simple components with high atom economy.