Site‐Selective Tertiary Alkyl–Fluorine Bond Formation from α‐Bromoamides Using a Copper/CsF Catalyst System. (10th June 2016)
- Record Type:
- Journal Article
- Title:
- Site‐Selective Tertiary Alkyl–Fluorine Bond Formation from α‐Bromoamides Using a Copper/CsF Catalyst System. (10th June 2016)
- Main Title:
- Site‐Selective Tertiary Alkyl–Fluorine Bond Formation from α‐Bromoamides Using a Copper/CsF Catalyst System
- Authors:
- Nishikata, Takashi
Ishida, Syo
Fujimoto, Ryo - Abstract:
- Abstract: A copper‐catalyzed site‐selective fluorination of α‐bromoamides possessing multiple reaction sites, such as primary and secondary alkyl−Br bonds, using inexpensive CsF is reported. Tertiary alkyl−F bonds, which are very difficult to synthesize, can be formed by this fluorination reaction with the aid of an amide group. Control experiments revealed that in situ generated CuF2 is a key fluorinating reagent that reacts with the tertiary alkyl radicals generated by the reaction between an α‐bromocarbonyl compound and a copper(I) salt.
- Is Part Of:
- Angewandte Chemie. Volume 128:Number 34(2016)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 128:Number 34(2016)
- Issue Display:
- Volume 128, Issue 34 (2016)
- Year:
- 2016
- Volume:
- 128
- Issue:
- 34
- Issue Sort Value:
- 2016-0128-0034-0000
- Page Start:
- 10162
- Page End:
- 10166
- Publication Date:
- 2016-06-10
- Subjects:
- Alkylierungen -- Fluorierungen -- Kupfer -- Radikale -- Reaktionsmechanismen
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201603426 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 2752.xml