Biomimetic Immuno‐Magnetosomes for High‐Performance Enrichment of Circulating Tumor Cells. Issue 36 (4th July 2016)

• Record Type: Journal Article
• Authors: Xiong, Ke; Wei, Wei; Jin, Yongjie; Wang, Shumin; Zhao, Dongxu; Wang, Shuang; Gao, Xiaoyong; Qiao, Chenmeng; Yue, Hua; Ma, Guanghui; Xie, Hai‐Yan
• Is Part Of: Advanced materials. Volume 28:Issue 36(2016)
• Page Start: 7929
• Page End: 7935
• Publication Date: 2016-07-04
• Subjects: biomimetics -- capture efficiency -- circulating tumor cells -- leukocyte backgrounds -- magnetic particles; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201601643
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : A novel biomimetic immuno‐magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti‐epithelial cell‐adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.