Spatio‐Design of Multidimensional Prickly Zn‐Doped CuO Nanoparticle for Efficient Bacterial Killing. Issue 18 (22nd August 2016)

• Record Type: Journal Article
• Authors: Wu, Runrun; Zhang, Hongbo; Pan, Jianming; Zhu, Hengjia; Ma, Yue; Cui, Wenguo; Santos, Hélder A.; Pan, Guoqing
• Is Part Of: Advanced materials interfaces. Volume 3:Issue 18(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-08-22
• Subjects: antibacterial -- multidimensional design -- nanopiercing -- prickly nanoparticles -- Zn‐doped CuO; Materials science -- Periodicals; 620.11
• DOI: 10.1002/admi.201600472
• Languages: English
• ISSNs: 2196-7350

Abstract

Abstract : Zinc‐doped copper oxide (Zn‐CuO) is a promising material for the development of antimicrobial materials due to its safety and the highly effective antibacterial activities against multidrug‐resistant bacteria. As known, the intracellular reactive oxygen species produced by Zn‐CuO nanomaterials play important role in bacterial killing; however, the relationship between their nanostructure and antibacterial activity has yet to be elucidated. In this study, we prepare, for the first time, Zn‐CuO nanoparticles with prickly nanostructures via a green sonochemical method. The resultant prickly Zn‐CuO nanoparticles exhibit strong antibacterial activity that can kill 99.0% of bacteria within 10 min under dark conditions and significantly hamper bacterial growth in Luria‐Bertani culture medium. It is also found that prickly Zn‐CuO nanoparticles show a nanopiercing process on bacterial membrane and subsequently lead to accelerated cytoplasma leakage. To further check the effect of nanopiercing on membrane damage and bacterial killing, Zn‐CuO nanorods are employed with two sharp tips for comparison. Due to the great change of nanopiercing process from multidimension (prickly) to 1D (rod‐like), the Zn‐CuO nanorods exhibit distinctly lower antibacterial activity compared with prickly Zn‐CuO nanoparticles. This finding definitely indicates the importance of nanostructures on the antibacterial activity of Zn‐CuO nanoparticles, i.e., architecture‐enhanced nanopiercing for bacterial killing. Abstract : A prickly Zn‐doped CuO nanoparticle exhibits enhanced antibacterial activities compared to Zn‐doped CuO nanorod. The evolutions of nanopiercing process from 1D to multidimension on bacterial cell wall contribute greatly to the enhanced bacterial killing.