Prevention of adhesion bands by ibuprofen‐loaded PLGA nanofibers. (3rd August 2016)

• Record Type: Journal Article
• Authors: Jamshidi‐Adegani, Fatemeh; Seyedjafari, Ehsan; Gheibi, Nematollah; Soleimani, Masoud; Sahmani, Mehdi
• Is Part Of: Biotechnology progress. Volume 32:Number 4(2016:Jul./Aug.)
• Page Start: 990
• Page End: 997
• Publication Date: 2016-08-03
• Subjects: intraperitoneal adhesion -- poly(lactic‐co‐glycolic acid) -- ibuprofen; Biotechnology -- Periodicals; Food industry and trade -- Periodicals; Bioengineering -- Periodicals; 660.6
• DOI: 10.1002/btpr.2270
• Languages: English
• ISSNs: 8756-7938

Abstract

Abstract : In this study, prevention of the adhesion bands and inflammatory features has been investigated using poly (lactic‐ co ‐glycolic acid)‐ibuprofen (PLGA‐IB) nanofibrous meshes in a mice model. To find the optimized membrane for prevention of postoperative adhesion bands, we have compared PLGA‐IB group with PLGA, IB, and control groups in a mice adhesion model. Two scoring adhesion systems were used to represent the outcome. According to the results obtained in this study, the PLGA‐IB nanofiber membrane showed a greater reduction in adhesion band than other groups. In conclusion, among FDA‐approved polymers and drugs, PLGA‐IB meshes could be applicable as a potential candidate for prevention of postoperative abdominal inflammation and adhesion bands formation. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:990–997, 2016