CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression. (18th April 2016)

• Record Type: Journal Article
• Authors: Downs, Isaac; Vijayan, Saptha; Sidiq, Tabasum; Kobayashi, Koichi S.
• Is Part Of: BioFactors. Volume 42:Number 4(2016:Jul./Aug.)
• Page Start: 349
• Page End: 357
• Publication Date: 2016-04-18
• Subjects: NLRC5 -- MHC class I -- NLR proteins -- CIITA; Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1285
• Languages: English
• ISSNs: 0951-6433

Abstract

Abstract: Major histocompatibility complex (MHC) class I and class II molecules play essential roles in the development and activation of the human adaptive immune system. An NLR protein, CIITA (MHC class II transactivator) has been recognized as a master regulator of MHC class II gene expression, albeit knowledge about the regulatory mechanism of MHC class I gene expression had been limited. Recently identified MHC class I transactivator (CITA), or NLRC5, also belongs to the NLR protein family and constitutes a critical regulator for the transcriptional activation of MHC class I genes. In addition to MHC class I genes, CITA/NLRC5 induces the expression of β2 ‐microglobulin, TAP1 and LMP2, essential components of the MHC class I antigen presentation pathway. Therefore, CITA/NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and class II pathways, respectively. © 2016 BioFactors, 42(4):349–357, 2016