Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue. Issue 12 (16th August 2016)

• Record Type: Journal Article
• Authors: Waffenschmidt, Tobias; Cilla, Myriam; Sáez, Pablo; Pérez, Marta M.; Martínez, Miguel A.; Menzel, Andreas; Peña, Estefanía
• Is Part Of: Journal of biomechanics. Volume 49:Issue 12(2016)
• Page Start: 2390
• Page End: 2397
• Publication Date: 2016-08-16
• Subjects: Ageing -- Anisotropic biological tissues -- Thick-walled tube -- Parameter identification; Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2016.01.043
• Languages: English
• ISSNs: 0021-9290

Abstract

Abstract: The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure–stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE − / − and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE − / − mice aortas exhibit a saturation-type increase with respect to age.