Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve. Issue 12 (16th August 2016)

• Record Type: Journal Article
• Authors: Joda, Akram; Jin, Zhongmin; Haverich, Axel; Summers, Jon; Korossis, Sotirios
• Is Part Of: Journal of biomechanics. Volume 49:Issue 12(2016)
• Page Start: 2502
• Page End: 2512
• Publication Date: 2016-08-16
• Subjects: Aortic valve -- Fluid–structure interaction -- Arbitrary Lagrangian Eulerian -- Anisotropic material model; Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2016.02.041
• Languages: English
• ISSNs: 0021-9290

Abstract

Abstract: This study developed a realistic 3D FSI computational model of the aortic valve using the fixed-grid method, which was eventually employed to investigate the effect of the leaflet thickness inhomogeneity and leaflet mechanical nonlinearity and anisotropy on the simulation results. The leaflet anisotropy and thickness inhomogeneity were found to significantly affect the valve stress–strain distribution. However, their effect on valve dynamics and fluid flow through the valve were minor. Comparison of the simulation results against in-vivo and in-vitro data indicated good agreement between the computational models and experimental data. The study highlighted the importance of simulating multi-physics phenomena (such as fluid flow and structural deformation), regional leaflet thickness inhomogeneity and anisotropic nonlinear mechanical properties, to accurately predict the stress–strain distribution on the natural aortic valve.