Ventromedial prefrontal damage causes a pervasive impairment of episodic memory and future thinking. (September 2016)

• Record Type: Journal Article
• Authors: Bertossi, Elena; Tesini, Chiara; Cappelli, Alessandro; Ciaramelli, Elisa
• Is Part Of: Neuropsychologia. Volume 90(2016)
• Page Start: 12
• Page End: 24
• Publication Date: 2016-09
• Subjects: ventromedial prefrontal cortex -- mental time travel -- autobiographical memory -- episodic future thinking -- temporal discounting -- default mode network; Neuropsychology -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Neuropsychologie -- Périodiques; Neuropsychology; Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.neuropsychologia.2016.01.034
• Languages: English
• ISSNs: 0028-3932

Abstract

Abstract: The ability to project oneself into the past and future to relive or pre-live personal experiences, known as mental time travel (MTT), is associated with activity in a core network of brain regions involving the ventromedial prefrontal cortex (vmPFC). We investigated whether (1) vmPFC is crucial for MTT, and (2) whether vmPFC is selectively involved in the construction of self-relevant events or also mediates construction of events happening to others. Patients with lesions to vmPFC (vmPFC patients) and healthy controls remembered personal past events and imagined personal future events across different timeframes, and imagined events to happen to a close or a distant other. Compared to the controls, vmPFC patients were impaired at constructing both past and future events, indicating that vmPFC is critical for MTT. vmPFC patients' ability to imagine personal future events was related to patients' temporal discounting rates. Patients, however, were also impaired at imagining other-related events, suggesting that self-relevance may not be a critical factor in explaining vmPFC's involvement in MTT. We suggest that vmPFC is crucial for the imagination of complex experiences alternative to the current reality, which serves construction of both self-relevant and other-relevant events. Highlights: vmPFC patients constructed personal past and future events low in episodic detail Episodic future thinking and temporal discounting were related in vmPFC patients vmPFC patients also had difficulties imagining others' experiences vmPFC may mediate construction of complex experiences alternative to reality