Early neurodevelopmental outcomes of infants with intestinal failure. (October 2016)

• Record Type: Journal Article
• Authors: So, Stephanie; Patterson, Catherine; Gold, Anna; Rogers, Alaine; Kosar, Christina; de Silva, Nicole; Burghardt, Karolina Maria; Avitzur, Yaron; Wales, Paul W.
• Is Part Of: Early human development. Volume 101(2016)
• Page Start: 11
• Page End: 16
• Publication Date: 2016-10
• Subjects: IF intestinal failure -- PN parenteral nutrition -- NEC necrotizing enterocolitis -- PT physiotherapy -- OT occupational therapy -- SLP speech and language pathology -- GA gestational age -- ELBW extremely low birth weight -- NICU neonatal intensive care unit -- MRI magnetic resonance imaging -- CNS central nervous system -- CP cerebral palsy -- NDI neurodevelopmental impairment -- SD standard deviation -- IQR interquartile range -- GM Prechtl's Assessment of General Movements -- AIMS Alberta Infant Motor Scale -- MAI Movement Assessment of Infants -- CA corrected age; Neurodevelopmental outcomes -- Intestinal failure -- Necrotizing enterocolitis -- Short bowel syndrome -- Gastroschisis; Fetus -- Periodicals; Neonatology -- Periodicals; Prenatal influences -- Periodicals; 612.65
• DOI: 10.1016/j.earlhumdev.2016.05.012
• Languages: English
• ISSNs: 0378-3782

Abstract

Abstract: Background: The survival rate of infants and children with intestinal failure is increasing, necessitating a greater focus on their developmental trajectory. Aims: To evaluate neurodevelopmental outcomes in children with intestinal failure at 0–15 months corrected age. Study design: Analysis of clinical, demographic and developmental assessment results of 33 children followed in an intestinal rehabilitation program between 2011 and 2014. Outcome measures included: Prechtl's Assessment of General Movements, Movement Assessment of Infants, Alberta Infant Motor Scale and Mullen Scales of Early Learning. Clinical factors were correlated with poorer developmental outcomes at 12–15 months corrected age. Results: Thirty-three infants (17 males), median gestational age 34 weeks (interquartile range 29.5–36.0) with birth weight 1.98 kg (interquartile range 1.17–2.50). Twenty-nine (88%) infants had abnormal General Movements. More than half had suspect or abnormal scores on the Alberta Infant Motor Scale and medium to high-risk scores for future neuromotor delay on the Movement Assessment of Infants. Delays were seen across all Mullen subscales, most notably in gross motor skills. Factors significantly associated with poorer outcomes at 12–15 months included: prematurity, low birth weight, central nervous system co-morbidity, longer neonatal intensive care admission, necrotizing enterocolitis diagnosis, number of operations and conjugated hyperbilirubinemia. Conclusion: Multiple risk factors contribute to early developmental delay in children with intestinal failure, highlighting the importance of close developmental follow-up. Highlights: Infants with intestinal failure present with multiple, significant medical co-morbidities. There is an increased risk of early developmental delays in this population, most notably in gross motor skill development. Specific factors related to intestinal failure may play a role in these delays, over and above the influence of prematurity.