Altered antibiotic tolerance in anaerobic digesters acclimated to triclosan or triclocarban. (November 2016)

• Record Type: Journal Article
• Authors: Carey, Daniel E.; McNamara, Patrick J.
• Is Part Of: Chemosphere. Volume 163(2016)
• Page Start: 22
• Page End: 26
• Publication Date: 2016-11
• Subjects: Cross-resistance -- Antimicrobial -- Ciprofloxacin -- Tetracycline -- Chloramphenicol; CDC Center for Disease Control -- TCS triclosan -- TCC triclocarban -- USEPA United States Environmental Protection Agency -- IC50 concentration that inhibits 50% of methane production -- COD chemical oxygen demand -- SRT solid retention time -- ATA anaerobic toxicity assay -- pATA prokaryotic anaerobic toxicity assay -- Kow octanol water partition coefficient -- VFA volatile fatty acid; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2016.07.097
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Bench-scale anaerobic digesters were amended to elevated steady-state concentrations of triclosan (850 mg/kg) and triclocarban (150 mg/kg) using a synthetic feed. After more than 9 solids retention time (SRT) values of acclimatization, biomass from each digester (and a control digester that received no antimicrobials) was used to assess the toxicity of three antibiotics. Methane production rate was measured as a surrogate for activity in microcosms that received doses of antibiotics ranging from no-antibiotic to inhibitory concentrations. Biomass amended with triclocarban was more sensitive to tetracycline compared to the control indicating synergistic inhibitory effects between this antibiotic and triclocarban. In contrast, biomass amended with triclosan was able to tolerate statistically higher levels of ciprofloxacin indicating that triclosan can induce functional resistance to ciprofloxacin in an anaerobic digester community. Highlights: Antimicrobials can alter anaerobic digester biomass tolerance to antibiotics. Triclocarban decreased tolerance of biomass to tetracycline (synergistic inhibition). Triclosan increased tolerance of biomass to ciprofloxacin (cross-resistance).