The chemical reactivities of DOPA and dopamine derivatives and their regioselectivities upon oxidative nucleophilic trapping. Issue 41 (13th October 2016)

• Record Type: Journal Article
• Authors: Cheah, Yong Shung; Santhanakrishnan, Sridhar; Sullivan, Michael B.; Neoh, Koon Gee; Chai, Christina L.L.
• Is Part Of: Tetrahedron. Volume 72:Issue 41(2016)
• Page Start: 6543
• Page End: 6550
• Publication Date: 2016-10-13
• Subjects: Catecholamine -- Oxidation -- Regioselectivity -- Semi-empirical -- Polymerisation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2016.08.068
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: The chemical reactivities of four catecholamines, N -acetyl dopamine (NADA) and its dehydro derivative (NAΔDA), N -acetyl 3, 4-dihydroxy-phenylalanine methyl ester (NADOPAME) and its dehydro derivative (NAΔDOPAME), under oxidative nucleophilic trapping and polymerisation conditions were compared and contrasted. Despite their structural similarities, varying reactivities and regioselectivities for oxidative nucleophilic trapping with ethanethiol were observed. This has possible implications on the use of these natural building blocks and their derivatives in the design and synthesis of biomimetic materials. Graphical abstract: