Sweet taste disorder and vascular complications in patients with abnormal glucose tolerance. (15th October 2016)

• Record Type: Journal Article
• Authors: Tsujimoto, Tetsuro; Imai, Kenjiro; Kanda, Sayaka; Kakei, Masafumi; Kajio, Hiroshi; Sugiyama, Takehiro
• Is Part Of: International journal of cardiology. Volume 221(2016)
• Page Start: 637
• Page End: 641
• Publication Date: 2016-10-15
• Subjects: GLP-1 glucagon-like peptide 1 -- NHANES National Health and Nutrition Examination Survey -- HbA1c glycated A1c -- GFR glomerular filtration rate -- NCHS National Center for Health Statistics -- MEC mobile examination center -- MDRD Modification of Diet in Renal Disease -- USDA US Department of Agriculture -- DHHS Department of Health and Human Services; Sweet taste disorder -- Ischemic heart disease -- Diabetes -- Abnormal glucose tolerance -- Sugar intake; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2016.07.062
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: It remains unknown whether taste disorders can be a risk factor for micro- and macro-vascular diseases in patients with abnormal glucose tolerance. Methods: A cross-sectional study in a nationally representative samples of 848 and 849 US adults (aged ≥ 40 years) with diabetes or prediabetes who had sweet and salt taste disorders, respectively, from the National Health and Nutrition Examination Survey 2011–2012. Results: Among the study population, 5.7% had sweet taste disorder and 8.6% had salt taste disorder. These data correspond to approximately 1.5 million and 1.8 million individuals with abnormal glucose tolerance aged 40 years or older in the US population, respectively. In the adjusted model, sweet taste disorder was significantly associated with complication of ischemic heart disease (adjusted odds ratio [OR], 2.45; 95% confidence interval [CI], 1.03–5.81; P = 0.04). Moreover, sweet taste disorder in patients with diabetes was significantly associated with diabetic retinopathy (adjusted OR, 2.89; 95% CI, 1.09–7.69; P = 0.03) and diabetic nephropathy (adjusted OR, 3.17; 95% CI, 1.07–9.36; P = 0.03). Meanwhile, salt taste disorder was not significantly associated with diabetic retinopathy, diabetic nephropathy, ischemic heart disease, or stroke. Total sugar intake was significantly higher in patients with sweet taste disorder than in those without it, whereas total daily intake of carbohydrate did not differ significantly. No significant association was observed between salt taste disorder and daily intake of sodium after multivariate analysis. Conclusions: Sweet taste disorder in patients with abnormal glucose tolerance was associated with increased sugar intake and vascular complications.