7 tesla T2*‐weighted MRI as a tool to improve detection of focal cortical dysplasia. Issue 3 (9th September 2016)

• Record Type: Journal Article
• Authors: Veersema, Tim J.; van Eijsden, Pieter; Gosselaar, Peter H.; Hendrikse, Jeroen; Zwanenburg, Jaco J.M.; Spliet, Wim G.M.; Aronica, Eleonora; Braun, Kees P.J.; Ferrier, Cyrille H.
• Is Part Of: Epileptic disorders. Volume 18:Issue 3(2016:Sep.)
• Page Start: 315
• Page End: 323
• Publication Date: 2016-09-09
• Subjects: epilepsy -- FCD -- cortical localization -- susceptibility weighted -- ultra‐high field -- magnetic resonance imaging; Epilepsy -- Periodicals; 616.853
• DOI: 10.1684/epd.2016.0838
• Languages: English
• ISSNs: 1294-9361

Abstract

Abstract: Focal cortical dysplasia is one of the most common underlying pathologies in patients who undergo surgery for refractory epilepsy. Absence of a MRI‐visible lesion necessitates additional diagnostic tests and is a predictor of poor surgical outcome. We describe a series of six patients with refractory epilepsy due to histopathologically‐confirmed focal cortical dysplasia, for whom pre‐surgical 7 tesla T 2 *‐weighted MRI was acquired. In four of six patients, T 2 * sequences showed areas of marked superficial hypointensity, co‐localizing with the epileptogenic lesion. 7 tesla T 2 * hypointensities overlying focal cortical dysplasia may represent leptomeningeal venous vascular abnormalities associated with the underlying dysplastic cortex. Adding T 2 * sequences to the MRI protocol may aid in the detection of focal cortical dysplasias.