Effects of vitamin D supplementation on glycated haemoglobin and fasting glucose levels in hypertensive patients: a randomized controlled trial. Issue 10 (28th July 2016)

• Record Type: Journal Article
• Authors: Grübler, M. R.; Gaksch, M.; Kienreich, K.; Verheyen, N.; Schmid, J.; ó Hartaigh, B.; Richtig, G.; Scharnagl, H.; Meinitzer, A.; Fahrleitner‐Pammer, A.; März, W.; Tomaschitz, A.; Pilz, S.
• Is Part Of: Diabetes, obesity & metabolism. Volume 18:Issue 10(2016)
• Page Start: 1006
• Page End: 1012
• Publication Date: 2016-07-28
• Subjects: cardiovascular disease -- randomised trial -- type 2 diabetes; Diabetes -- Periodicals; Obesity -- Periodicals; Metabolism -- Disorders -- Periodicals; Clinical pharmacology -- Periodicals; 616.462
• DOI: 10.1111/dom.12709
• Languages: English
• ISSNs: 1462-8902

Abstract

Abstract : Aim: To investigate the efficacy of vitamin D supplementation on glycaemic control. Methods: The Styrian Vitamin D Hypertension Trial was a single‐centre, double‐blind, placebo‐controlled study conducted between 2011 and 2014 at the Medical University of Graz, Austria. We enrolled 200 people with arterial hypertension and 25‐hydroxyvitamin D [25(OH)D] concentrations <30 ng/mL. Study participants were randomized to receive either 2800 IU of vitamin D or placebo per day for 8 weeks. The present study was a post hoc analysis that incorporated an analysis of covariance (ancova ) approach, while adjusting for baseline differences. Results: A total of 185 participants [mean ± standard deviation age, 60.1 ± 11.3 years; 47% women; mean 25(OH)D 21.2 ± 5.6 ng/mL, mean glycated haemoglobin (HbA1c) 44.8 ± 11.8 mmol/mol and mean body mass index 30.4 ± 5.4 kg/m 2 ] completed the trial.ancova showed a mean treatment effect [95% confidence interval (CI)] on HbA1c of −3.52 (−6.7 to −0.34) mmol/mol (p = .045). There was no difference in fasting glucose −4.7 mg/dL (95% CI −16.3 to 6.9; p = .426). Conclusions: Vitamin D supplementation in obese hypertensive patients with low 25(OH)D reduces HbA1c levels. This finding warrants further investigation into potential vitamin D effects on glucose homeostasis.