Distal mean nocturnal baseline impedance on pH‐impedance monitoring predicts reflux burden and symptomatic outcome in gastro‐oesophageal reflux disease. Issue 8 (24th August 2016)

• Record Type: Journal Article
• Authors: Patel, A.; Wang, D.; Sainani, N.; Sayuk, G. S.; Gyawali, C. P.
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 44:Issue 8(2016)
• Page Start: 890
• Page End: 898
• Publication Date: 2016-08-24
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.13777
• Languages: English
• ISSNs: 0269-2813

Abstract

SUMMARY: Background: Mean nocturnal baseline impedance (MNBI), a novel pH‐impedance metric, may be a surrogate marker of reflux burden. Aim: To assess the predictive value of MNBI on symptomatic outcomes after anti‐reflux therapy. Methods: In this prospective observational cohort study, pH‐impedance studies performed over a 5‐year period were reviewed. Baseline impedance was extracted from six channels at three stable nocturnal 10‐min time periods, and averaged to yield MNBI. Distal and proximal oesophageal MNBI values were calculated by averaging MNBI values at 3, 5, 7 and 9 cm, and 15 and 17 cm respectively. Symptomatic outcomes were measured as changes in global symptom severity (GSS, rated on 100‐mm visual analogue scales) on prospective follow‐up after medical or surgical anti‐reflux therapy. Univariate and multivariate analyses assessed the predictive value of MNBI on symptomatic outcomes. Results: Of 266 patients, 135 (50.8%) were tested off proton pump inhibitor (PPI) therapy and formed the study cohort (52.1 ± 1.1 years, 63.7% F). The 59 with elevated acid exposure time (AET) had lower composite and distal MNBI values than those with physiological AET ( P < 0.0001), but similar proximal MNBI ( P = 0.62). Linear AET negatively correlated with distal MNBI, both individually and collectively (Pearson's r = −0.5, P < 0.001), but not proximal MNBI (Pearson's r = 0, P = 0.72). After prospective follow‐up (94 patients were followed up for 3.1 ± 0.2 years), univariate and multivariate regression models showed that distal MNBI, but not proximal MNBI, was independently predictive of linear GSS improvement. Conclusions: Distal oesophageal MNBI negatively correlates with AET and, when assessed off PPI therapy, is independently predictive of symptomatic improvement following anti‐reflux therapy.