Levels of CD40L and other inflammatory biomarkers in obese and non‐obese women with polycystic ovary syndrome. (29th August 2016)

• Record Type: Journal Article
• Authors: Sarray, Sameh; Almawi, Wassim Y.
• Is Part Of: American journal of reproductive immunology. Volume 76:Number 4(2016)
• Page Start: 285
• Page End: 291
• Publication Date: 2016-08-29
• Subjects: CD40L -- CRP -- cytokines -- polycystic ovary syndrome; Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12549
• Languages: English
• ISSNs: 1046-7408

Abstract

Abstract : Problem: We investigated whether changes in sCD40L, hs‐CRP, IL‐6, and TNF‐α levels are associated with polycystic ovary syndrome (PCOS). Method of study: Case–control study involving 143 women with and 165 women without PCOS. Result(s): Reduced sCD40L, and increased hs‐CRP and IL‐6, but not TNF‐α, levels were seen between cases and controls. ROC analysis demonstrated high sensitivity and specificity for sCD40L and hs‐CRP as PCOS predictors. Altered sCD40L levels were associated with PCOS, irrespective of body weight. Significant differences in IL‐6 levels were seen between non‐obese subjects and for TNF‐α in obese subjects. sCD40L correlated negatively with age, insulin, HOMA‐IR, LH, free testosterone, FAI, and hirsutism, but positively with SHBG. CRP correlated positively with BMI, insulin, HOMA‐IR, free testosterone, and hirsutism. IL‐6 correlated positively with hirsutism. TNF‐α correlated positively with age, but negatively with insulin and HOMA‐IR. Conclusion: CD40L, more than IL‐6, or TNF‐α, constitutes a predictor to explain PCOS and associated features.