Stereoselective synthesis of the KJ ring system of yessotoxin by Pd(II)-catalyzed cyclization. Issue 39 (28th September 2016) - Yokoyama, Hajime
Graphical abstract: Highlights: Stereoselective synthesis of the KJ ring system of yessotoxin. Pd(II)-catalyzed cyclization reaction of trisubstituted allylic alcohol. Highly stereoselective and mild reaction. Construction of a quaternary stereocenter. Abstract: Yessotoxin was isolated from the digestive glands of the scallop, Patinopecten yessoensis, and would be of use as a promising therapeutic tool. We attained the stereoselective construction of KJ ring system of yessotoxin by the intramolecular cyclization of the trisubstituted allylic alcohol using Pd(II) catalyst.