A new theoretical model for transmembrane potential and ion currents induced in a spherical cell under low frequency electromagnetic field. Issue 7 (20th July 2016)

• Record Type: Journal Article
• Authors: Zheng, Yu; Gao, Yang; Chen, Ruijuan; Wang, Huiquan; Dong, Lei; Dou, Junrong
• Is Part Of: Bioelectromagnetics. Volume 37:Issue 7(2016:Oct.)
• Page Start: 481
• Page End: 492
• Publication Date: 2016-07-20
• Subjects: Nernst‐Plank equation -- membrane ionic current -- ionic mobility -- calculating model -- Hodgkin‐Huxley model; Electromagnetism -- Physiological effect -- Periodicals; 571.47
• DOI: 10.1002/bem.21993
• Languages: English
• ISSNs: 0197-8462

Abstract

Abstract : Time‐varying electromagnetic fields (EMF) can induce some physiological effects in neuronal tissues, which have been explored in many applications such as transcranial magnetic stimulation. Although transmembrane potentials and induced currents have already been the subjects of many theoretical studies, most previous works about this topic are mainly completed by utilizing Maxwell's equations, often by solving a Laplace equation. In previous studies, cells were often considered to be three‐compartment models with different electroconductivities in different regions (three compartments are often intracellular regions, membrane, and extracellular regions). However, models like that did not take dynamic ion channels into consideration. Therefore, one cannot obtain concrete ionic current changes such as potassium current change or sodium current change by these models. The aim of the present work is to present a new and more detailed model for calculating transmembrane potentials and ionic currents induced by time‐varying EMF. Equations used in the present paper originate from Nernst‐Plank equations, which are ionic current‐related equations. The main work is to calculate ionic current changes induced by EMF exposure, and then transmembrane potential changes are calculated with Hodgkin‐Huxley model. Bioelectromagnetics. 37:481–492, 2016. © 2016 Wiley Periodicals, Inc.