New chloramphenicol Schiff base ligands for the titanium-mediated asymmetric aldol reaction of α, β-unsaturated aldehydes with diketene: a short synthesis of atorvastatin calcium. Issue 79 (9th August 2016)

• Record Type: Journal Article
• Authors: Wang, Haifeng; Yan, Linjie; Xiong, Fangjun; Wu, Yan; Chen, Fener
• Is Part Of: RSC advances. Volume 6:Issue 79(2016)
• Page Start: 75470
• Page End: 75477
• Publication Date: 2016-08-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra15304f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Several novel chiral Schiff base ligands were prepared from a commercially available chloramphenicol base and applied to the titanium-mediated asymmetric aldol reaction of diketene with various α, β-unsaturated aldehydes. Abstract : Several novel chiral Schiff base ligands were prepared from a commercially available chloramphenicol base and applied to the titanium-mediated asymmetric aldol reaction of diketene with various α, β-unsaturated aldehydes. This reaction proceeded in good yield with high enantioselectivity. The synthetic utility of this methodology was demonstrated in the short synthesis of atorvastatin calcium.