Secondary metabolites with chemical diversity from the marine-derived fungus Pseudallescheria boydii F19-1 and their cytotoxic activity. Issue 80 (11th August 2016)

• Record Type: Journal Article
• Authors: Lan, Wen-Jian; Wang, Kun-Teng; Xu, Meng-Yang; Zhang, Jing-Jing; Lam, Chi-Keung; Zhong, Guo-Hua; Xu, Jun; Yang, De-Po; Li, Hou-Jin; Wang, Lai-You
• Is Part Of: RSC advances. Volume 6:Issue 80(2016)
• Page Start: 76206
• Page End: 76213
• Publication Date: 2016-08-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra06661e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Twenty-five compounds with chemical diversity including five new compounds were isolated from the marine-derived fungus Pseudallescheria boydii F19-1. Five compounds displayed significant cytotoxicity against Sf9 cells. Abstract : Two aromadendrane-type sesquiterpene diastereomers pseuboydones A, B (1, 2 ), two diketopiperazines pseuboydones C, D (3, 4 ), and a cyclopiazonic acid analogue pseuboydone E (13 ) together with twenty known compounds (5–12, 14–25 ) were isolated from the culture broth of the marine-derived fungus associated with the soft coral Lobophytum crassum . The twenty-five compounds in total belong to diverse structural classes, including sesquiterpenoids, diketopiperazines, alkaloids, meroterpenoids, pyrazines, and polyketides. The structures of the new compounds were elucidated using HRMS, 1D and 2D NMR spectroscopic data, ECD calculations, and X-ray single crystal diffraction analysis. Compounds3, 11, 16, 17, and18 displayed significant cytotoxicity against the Sf9 cells from the fall armyworm Spodoptera frugiperda .